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KMID : 1094720070120040359
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Biotechnology and Bioprocess Engineering
2007 Volume.12 No. 4 p.359 ~ p.365
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Effect of metabolic structures and energy requirements on curdlan production by Alcaligenes faecalis
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Zheng Zhi-Yong
Lee Jin-Woo
Zhan Xiao-Bei
Shi Zhong-Ping
Wang Lei
Zhu Li
Wu Jian-Rong
Lin Chi-Chung
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Abstract
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A comprehensive metabolic network was proposed forAlcaligenes faecalis and employed in a stoichiometrically based flux balance model for curdlan production optimization. The maximal yield of curdlan was evaluated for curdlan batch production. Various metabolic structures and metabolic pathway distributions related with the curdlan maximal yield was evaluated. The results showed that the energy efficiency rather than the substrate supply was the major constraint for the enhancement of curdlan production. The increase in specific rate of glucose uptake could enhance curdlan production yield due to the decrease of the ratio of metabolic maintenance to substrate consumption. However, some of the energy loss and nutrient limitation associated with the increase of metabolic maintenance would adversely affect the conversion efficiency of the substrate.
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KEYWORD
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Alcaligenes faecalis, bioenergetics, curdlan, metabolic flux analysis
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